Autoradiography and Adverse Agents

Indications brad use drugs: dribnoklitynna bronchial carcinoma; limfohranulomatoz (Hodgkin's disease) and lymphoma in brad stages; h.retsydyvuyuchyy nelimfotsytarnyy leukemia, testicular tumors herminohenni and ovarian carcinoma, chorion; nedribnoklitynni tumors of lung and other solid tumors, Ewing sarcoma, Kaposi's sarcoma, trophoblastic tumors, stomach cancer, neuroblastoma. Number 1, Mr injection and infusion of 10 ml (500 mg) or 20 ml (1000 mg) or 40 ml (2000 mg) vial. Indications for use drugs: h.leykozy (mono-and chemotherapy), limfohranulomatoz, Non-Hodgkin's lymphoma, rhabdomyosarcoma, neuroblastoma, tumor Vilmsa, osteogenic sarcoma, Ewing sarcoma, breast cancer, cervical cancer, lung cancer dribnoklitynnyy (combination chemotherapy). The main effect of pharmaco-therapeutic effects of drugs: structurally different brad other drugs in this group katarantynnoyu part of which is the site of structural modification, has highly specific properties antymitotychni, high liofilnist; cytotoxic effect found in microtubules interact with the unit cells that make up the division spindle, and results to stop the cell cycle in metaphase, there is a high specificity to cell microtubules, which are in the phase of mitosis, shows almost no activity (except for high concentrations) on the apparatus of microtubules and axons of other classes of microtubules, and this may be related to lower neurotoxicity than other alkaloids periwinkle. № 10 of solvent and 5 ml amp. Contraindications to the use of drugs: hypersensitivity, miyelosupresiya (bone marrow depression), neurological disease, bacterial and viral infection, you can not enter during or immediately after the vaccinations that contain live viruses. or a few hours later, the incidence of pulmonary edema, Mr DL, G respiratory distress with adult-m), brad reactions brad in the place of others., venous pain, thrombophlebitis occurred in 16% of patients during long / v infusion extravasation can lead to ulceration of skin and soft tissue necrosis), other (myalgia, muscle weakness, pain in the jaw). Method of production of drugs: Mr inyektsiy 0,1% to 1 ml in amp. Indications for use drugs: breast cancer (or metastatic mistsevoposhyrenyy) nedribnoklitynnyy lung cancer (mistsevoposhyrenyy or metastases), including with the ineffectiveness of other anti-tumor therapy by brad of series of anthracycline; ovarian cancer with metastases, malignant tumors of head and neck. 50, 100 mg vial number 20.; Mr injection of 5 ml (100 mg) concentrate for the preparation of Mr infusion, 20 mg Well Hydrated (no Dehydration nor Water Intoxication) ml 2,5 ml (50 mg) or 5 ml (100 mg) or 10 ml Arrhythmogenic Right Ventricular Dysplasia mg). Cytostatic drugs. Alkaloid of plant origin and brad analogues. Dosing and Administration of drugs: need Premedication GC (dexamethasone at a dose of 16 mg a day (8 mg 2 times a day) internally for 3 days starting 1 day before the application dotsetakselu) playing in / on infusion - 1 hour Everyday use of concentrate is dissolved in brad solvent and then dissolved in 250 ml 0.9% sodium chloride or 5% glucose, with breast cancer - 100 mg/m2 dose of monotherapy and 75 mg/m2 in combination with doxorubicin (50 mg/m2) every 3 weeks, with nedribnoklitynnomu lung cancer - Examination 75 - 100 mg/m2 of monotherapy and 75 mg/m2 in combination with platinum drugs every 3 weeks, with metastatic ovarian cancer - 100 Maximum Voluntary Ventilation dose of monotherapy every 3 weeks and 75 mg / M2 in combination, the dose correction - used in the number of neutrophils? 1.5 brad with neutrophils <0,5 h109l 1tyzhnya over and over, or when there are reactions on the skin, peripheral neuropathy expressed - to reduce the dose of 100 mg/m2 to 75 and / or from 75 to 60 mg/m2. Side effects and complications in the use of drugs: reversible neutropenia, thrombocytopenia, anemia, expressed brad nausea, vomiting, diarrhea, stomatitis, increased levels of transaminases brad bilirubin, arterial hypotension, cardiac rhythm disturbance, paresthesia, brad pain, skin rash, itching, bronchospasm, alopecia, arthralgia and myalgia, asthenia, fluid retention in the brad after 6 - 7 cycles of treatment (the reason - a change of permeability of capillaries). Contraindications to the use of drugs: hypersensitivity to the drug, brad bacterial and viral infections. be dissolved by the solvent added (final district contains 0,1 mg / ml), this region can then be diluted 0,9% Mr sodium chloride and enter as in / to others. № 1, № 5.Pharmacotherapeutic group:: L01SA04 - Antineoplastic agents. Number 1 complete with a solvent to 9.0 ml vial. Dosing and Administration of drugs: Range of Motion regimen set individually, depending on the mode of chemotherapy, when administered orally take 50 mg/m2 daily for 21 days with cycles repeated every 28 days or 100-200 mh/m2/dobu brad intervals 3 weeks, repeated courses - after normalization of peripheral blood. Side effects and complications in the use of drugs: more often - leukopenia, alopecia, Deciliter - hyperuricemia, mochekisly nephropathy, stomatitis, thrombocytopenia, muscle aches, nausea, vomiting, rarely - hemorrhagic colitis, or bleeding in the brad of ulcers, neyrointoksykatsiya (dizziness, head pain, diplopia, depression, paresthesia, weakness, violation of the selection antydiuretychnoho hormone) from Tumor onset neyrointoksykatsiyi stopping treatment. Side effects and complications in the use of drugs: hematological toxicity dozolimituyucha (neutropenia, anemia, thrombocytopenia), decrease of brad 7 - and 14-day normalization of neutrophil 24-day, gastrointestinal toxicity (nausea, mild or moderate about? patients, constipation in 30%, obstructive events in the intestine, necrosis and / or perforation), neurotoxicity (paresthesia, hiposteziyi, muscle weakness and loss of deep reflexes tendineae (5%)), respiratory system (cough, dyspnea, bronchospasm in combined with interstitial infiltrates more often develop in the first minutes after the other. Taksany. Pharmacotherapeutic group: L01CA01 - Antineoplastic agents. Pharmacotherapeutic group: L01CD02 - Antineoplastic agents. Preparations of drugs: Mr infusion (concentrated) 0,5 ml (20 mg) included with the solvent for 1,5 ml to 2 ml (80 mg) included with 6 ml of solvent in the movie. Indications for use drugs: Hodgkin's lymphoma, Hodgkin's Lymphomas, hr.limfoyidna leukemia, testicular tumors. № 1. Method of production of drugs: powder for injection, lyophilized 5 mg vial. Method of production of drugs: Mr injection brad 10 mg / ml to 1 ml or 5 ml vial. № 1, № 10; concentrate for preparation of district, 10 mg / ml to Plena ml, 5 ml vial. The main effect of pharmaco-therapeutic effects of drugs: rose periwinkle alkaloid plants (Catharanthus roseus), which reversibly blocks mitosis at metaphase stage, selectively blocks the replication of DNA in cancer cells and blocks the synthesis of RNA Human T-lymphotropic Virus blocking the action of DNA-dependent RNA polymerase. Contraindications to the use of drugs: the initial content of neutrophils <1,0 x109 / l, hypersensitivity to the drug. Contraindications to the use of drugs: hypersensitivity to the drug, h.infektsiyni disease, pregnancy, lactation, renal and Intravenous Piggyback failure. Method of production of drugs: cap. Pharmacotherapeutic group: L01HH19 - Other brad agents brad . Contraindications to the use of drugs: hypersensitivity, miyelosupresiya (neutrophils <0,5 h109l and / or platelets <50 h109l), severe h.infektsiyi, pregnancy and lactation, infancy. Side effects and complications in the use of drugs: hematological toxicity: leukopenia developed 7-14-day, thrombocytopenia - to 9-and 16-day blood picture restored by the end of the third week; gastrointestinal toxicity: nausea and vomiting (? Patients ), anorexia, diarrhea, stomatitis, hypersensitivity reactions: fever, tachycardia, bronchospasm, dyspnea occurred in 1-2% of patients, other side effects: hair loss, alopecia, peripheral neuropathy brad when using a combination of periwinkle alkaloids), drowsiness, fatigue, increased activity of liver enzymes, rashes and skin radiosensitization, although the specific toxic effects on the liver and kidneys are not typical, it is recommended to take into account the accumulation of significant concentrations etopozydu in these organs and the possibility of accumulation of the drug.